Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2020
  • Volume: 13
  • Issue: 10

Development and validation of method for the estimation of clobazam api in clobazam oral suspension 2.5mg/ml by power x-ray diffractometer (pxrd)

1Research Scholar (Chemistry), Vels University, Pallavaram, Chennai - 600043, Tamil Nadu, India

2Former Professor (Chemistry), Vels University, Pallavaram, Chennai - 600043, Tamil Nadu, India

3Professor (Chemistry), Vels University, Pallavaram, Chennai - 600043, Tamil Nadu, India

4Head of the Department (Chemistry), Vels University, Pallavaram, Chennai - 600043, Tamil Nadu, India

*Corresponding Author E-mail: sudhirsadul@rediffmail.com

Online published on 28 October, 2020.

Abstract

A PXRD quantitative method is developed for the Identification of Clobazam API[1] in Clobazam Oral Suspension 2.5mg/mL by using PXRD. The PXRD conditions for the Slow scan method developed for the identification of Clobazam API polymorph with a radiation source of Copper Kα1 ( λ = 1.54060A°). The Angular range was 3.5 to 45.0° 2θ with the Voltage and Current set to 40kV & 40mA and a step size of 0.03° along with sample rotation of 5rpm. The scan type is Locked coupled, continuous with a high sensitive Lynxeye XET detector. The method developed was validated[2] for Specificity, Method Precision, Intermediate Precision and Robustness. The PXRD Method was found to be specific, Precise and robust for the identification of Clobazam API in Clobazam Oral suspension 2.5mg/mL by PXRD.

Keywords

Power X-Ray Diffactometer (PXRD), Clobazam API, Clobazam oral suspension 2.5mg/Ml