Cognition enhancing potential of Sesbania grandiflora fruit extract in scopolamine induced amnesia in mice

Morris water maze (MWM) and Elevated plus maze (EPM) test was done to evaluate cognitive performance. To explore beneficial effect of various extracts of fruits of Sesbania grandiflora PESG, BESG, CESG, AESG, EESG was administered to mice for 15 days. Scopolamine (0.4mg/kg, i.p) was administered to mice after 45 minutes of extract administration on 15^th day. Piracetam (200mg/kg p.o.) was used as standard drug. Various biochemical parameters such as acetylcholineesterase (AchE), malondiadehyde (MDA), and Glutathion level (GSH) from brain homogenate were evaluated on 19^th day.

Pretreatment with BESG, CESG, AESG, EESG extract of Sesbania grandiflora (200mg/kg p.o) showed increase in transfer latency (TL) and increase in inflexion ratio (IR) in EPM and increase in escape latency time (ELT) and time spend in target quadrant (TSTQ) in MWM while decrease in TL and IR in EPM and decrease in ELT and TSTQ was observed in scopolamine induced amnesia. Pretreatment of BESG, CESG, AESG, EESG extract of fruits of Sesbania grandiflora significantly decrease MDA level and increases GSH level as compared to scopolamine induced amnesic mice.

The findings from present investigation may conclude that extracts of fruits of Sesbania grandiflora possesses cognition enhancing property in scopolamine induced amnesia in mice.