Identification of novel dipeptidyl peptidase -IV inhibitors from Ferula asafoetida through GC-MS and molecular docking studies

Diabetes mellitus (DM), a metabolic syndrome is marked by high measures of blood glucose due to lack of insufficient secretion of insulin. In the present study, photochemical compounds from Ferula asafoetida plant seeds were extracted and were analyzed about its inhibitory effects against Dipeptidyl peptidase (DPP)-IV using autodock studies. The GC-MS analysis confirmed that 12 active compounds were present in seed extract. Molecular docking studies showed four compounds viz., Ethoxydi (tert-butyl) silane, 9,12-octadecadienoic acid, Methyl- Tetra- decanoate and Hexadecanoic showed better inhibitory effect compared with standard DPP-IV inhibitor saxagliptin. In future these identified compounds can be used as a potential lead molecule for diabetic treatment compared to the standard drugs.