Design, development and characterization of self nano emulsifying drug delivery systems for repaglinide

In the current study we have explored Self Nano Emulsifying Drug delivery system (SNEDDS) to enhance solubility and dissolution profile of repaglinide. These are thermodynamically stable isotropic mixture of drug dissolved in oil, surfactant and co-surfactant that when introduced into an aqueous medium under gentle agitation form a spontaneous oil-in-water nanoemulsion with a droplet size less than 200 nm. Various oils, surfactant and co- surfactants were examined for formation of SNEDDS. From the Pseudo Ternary Phase diagram the optimized formulations were selected based upon the ability to incorporate more amount oil and formation of nano sized drop. The selected formulations were characterized for % transparency and globule size detection which was around 150nm. Formulations F5 ( oil -5% surfactant-80% co- surfactant-15%) and F10 ( oil -5% surfactant-75% co- surfactant-20%) has shown enhanced advantage of SNEDDS over pure drug where around 98% of drug was released in 60mins, for pure drug it shows only 32% in 60mins which may be attributed low globule size can be correlated to particle size determination studies showing around 15nm globule size for F5 and F10 formulations that leads to increase in interfacial area which leads to enhanced solubility.