Teratogenic effect of ethanolic extract of Solanum xanthocarpum berries in zebrafish embryo

Zebrafish model produce hundreds of offspring at weekly intervals providing scientists with an ample supply of embryos to study. As zebrafish eggs are fertilised and develop outside the mother’s body it is an ideal model organism for studying early development. In our present investigation we carried out the teratogenic effect of ethanolic extract of Solanum xanthocarpum berries in zebrafish embryo. Teratology is the study of abnormal development in embryo and causes congenital malformation or birth defects. Solanum xanthocarpum berries were extracted and prepared the five different concentrations of the extract 10%, 5%, 1%, 0.5%, and 0.1% respectively. The embryo-toxic effects, hatchability, and morphological abnormalities of extract treated embryos were determined. Zebrafish embryos exposed to different concentrations of Solanum xanthocorpum extract was proven to have embryotoxic (lethal) and teratogenic effects.