1department of General, Bioinorganic, Physical and Colloidal Chemistry, Danylo Halytsky Lviv National Medical University, 69 Pekarska, Lviv, 79010, Ukraine.
2Department of Organic Chemistry, Ivan Franko National University of Lviv, 6 Kyryla and Mefodia, Lviv, 79005, Ukraine.
Online published on 15 February, 2021.
By the reaction of furan-2-carboxylic acids with diazonium salts 1a-e the arylfuran-2-carboxylic acids 3a-e were synthesized. Acids 3a-e were transformed into appropriated acylchlorides 4a-e and were used for preparation of N-(R1-phenyl)-5-(R-phenyl)-2-furamides 6a-k. The structures of target compounds 6a-k were confirmed by using 1H NMR spectroscopy and elemental analysis. The compounds 6d-f with high antimicrobial activity against C. Neoformans ATCC 208821 were identified. It also have been found that compound 6i to be high active and against PC-3 Prostate Cancer cell lines (GP = 34.42) and 6f SR Leukemia cell lines (GP = 59.81).
Organic synthesis, Furan, N-(R1-phenyl)-5-(R-phenyl)-2-furamides, Pharmacological screening, Antimicrobial activity, Anticancer activity
