Synthesis and characterization of 1,3,4-oxadiazole derivatives as potential anti-inflammatory and analgesic agents

A novel series of substituted 1,3,4-oxadiazole derivative were synthesized by condensing different amine with 2-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl) phenyl acetate (III) in presence of formaldehyde. The structure of these novel synthesized compounds was characterized on the bases of physicochemical, spectral and elemental analysis. All newly synthesized compounds were tested in vivo for their anti-inflammatory activity by carrageenan induced rat paw oedema model. The compounds, which showed good anti-inflammatory activity further screened for their analgesic, antipyretic and ulcerogenic activity. Results of acute anti-inflammatory studies showed compounds IVa, IVb, IVd and IVe showed promising activity and in analgesic studies compound IVa, and IVb showed better activity as compared to standard drug aspirin.Compound IVa showed good antipyretic activity and less ulcerogenic activity as compared to standard drug aspirin.