1Department of Pharmaceutic's, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune, 412206, Maharshtra, India
2Department of Pharmaceutic's, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune, 412206, Maharshtra, India
3Department of Pharmacology, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune, 412206, Maharashtra, India
4Department of Pharmaceutic's, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune, 412206, Maharshtra, India
5Department of Pharmacology, Rajgad Dnyanpeeth's College of Pharmacy, Bhor, Pune, 412206, Maharashtra, India
The current investigation is to development andevaluation of HPMC based floating oral In situ gel of Pantoprazole Sodium.
Six formulations were formulate 2*3 factorial design.batch F-6 gives newer alternatives use of natural biodegradable polymer in situ gel formulation. Drug, Excipients and polymer compatibility studies were performed by FTIR and DSC.
The formulation was optimized gelling capacity, drug contentrange 92.93±0.10%to 96.83±.0.15%.percentage yield is 64.00%, 75.93%, 87.83%,. 93.21% and 95.25% and 97.07% respectively. The consistency of all the formulations was in the range 5.0±0.1 to 7.1±0.1 mm. The consistency of all the formulations.the formulated gel The pH of all the formulations was found to be 6.5 ±1.0.viscosity 1.440, 1.500, 1.560, 3.708, 3.182, 4.000
It is to obtain the increased residence time and sustained drug release. The gel formed in situ afforded sustained drug release over 8 hrs periods. The formulations exhibited therapeutic efficacy.
Oral Floating gel, sustained Release, HPMC, Calcium Carbonate, Pantoprazole Sodium
