Research Journal of Pharmacy and Technology

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterised by synovial inflammation, auto-antibody production, cartilage and bone deformity, anti-citrullinated protein antibody and hyperplasia and can cause cartilage and bone damage as well as disability. worldwide about 1% of adult population is affected by rheumatoid arthritis. It is the one of the most leading cause of disability with no ultimate cure. Many of the currently available antiarthritic drugs serve to manage only the symptomatic relief and are associated with adverse effects. Number of herbs have proven for potential antiarthritic activity in preclinical and clinical studies conducted. Zingiber officinale and Braccica oleraceae are two drugs that act on different pathophysiological mechanisms of arthritis. Hence the aim of this study was to evaluate the synergistic potential of the combination in rheumatoid arthritis. Complete Freunds Adjuvant (CFA) 0.1ml was used as an inducer and both the drugs were evaluated individually and in 1: 1 combination at (50, 100, 200mg/kg) doses. Parameters like paw oedema, percentage inhibition of paw oedema and serum SGOT and SGPT were measured in order to evaluate the ability of drugs in improving situation of Rheumatoid arthritis. The results indicated dose dependent antiarthritic action of both the individual drugs as well as the combination. Also, the antiarthritic action of combinations was found to be significantly greater than that of individual drugs thereby justifying the synergistic effect of the two drugs.