A Prospective Study of Propranolol and Flunarizine in the Prophylactic Therapy of Migraine in a Tertiary Care Hospital

Migraine is a common, recurrent, severe headache that interferes with normal functioning and quality of life (QOL). This prospective observational study was conducted to evaluate and compare the effectiveness and safety flunarizine(10mg), calcium channel antagonist, and propranolol(40mg) in the prophylaxis of migraine with or without aura. This Study included 70 patients of migraine and was divided into 2 treatment groups. SF 36 v1 questionaire were used for the evaluation of health related QOL. Both treatment groups led to a significant reduction in severity, frequency and duration after one month. The difference between two treatments was statistically significant. Sedation was noted with both treatments. Propranolol can be the better treatment for reducing the severity and frequency of migraine.