1Asfendiyarov Kazakh National Medical University, 050000, Almaty, Kazakhstan
2Institute of Chemical Sciences named after A.B. Bekturov, 050010, Almaty, Kazakhstan
3GxP Company LLP, 050059, Almaty, Kazakhstan
4University of Mississippi, 38677, Missisipi, USA
5Sh. Ualikhanov Kokshetau State University, 202000, Kokshetau, Kazakhstan
Online published on 16 June, 2020.
P-fluorine, m-fluorine, o-fluorinebenzoates of 1-propyl-4-hydroxypiperidine and 1-benzyl-4-hydroxypiperidine p-fluorobenzoate have been synthesized, which showed local anesthetic activity of varying degrees. Fluorobenzoic esters of secondary alcohols cause deep and prolonged anesthesia, the introduction of fluorine leads to local anesthetics with varying degrees of effectiveness.
P-fluorine, m-fluorine, o-fluoro-benzoylcarbonyl chloride, N-propylpiperidin-4-one, N-benzylpiperidin-4-one, esters, local anesthetic activity
