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P-fluorine, m-fluorine, o-fluorinebenzoates of 1-propyl-4-hydroxypiperidine and 1-benzyl-4-hydroxypiperidine p-fluorobenzoate have been synthesized, which showed local anesthetic activity of varying degrees. Fluorobenzoic esters of secondary alcohols cause deep and prolonged anesthesia, the introduction of fluorine leads to local anesthetics with varying degrees of effectiveness.
P-fluorine, m-fluorine, o-fluoro-benzoylcarbonyl chloride, N-propylpiperidin-4-one, N-benzylpiperidin-4-one, esters, local anesthetic activity
