Research Journal of Pharmacy and Technology

SCOPUS
  • Year: 2020
  • Volume: 13
  • Issue: 6

Gastroprotective Effect of Chloris paraguaiensis Steud Plant Extract in Various Experimental Models

1Department of Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Anantapur, Ananthapuramu, Andhra Pradesh, India

2Department of Pharmacology, Sri Venkateswara College of Pharmacy, RVS Nagar, Chittoor, Andhra Pradesh, India

3Department of Chemical Engineering, Jawaharlal Nehru Technological University, Anantapur, Ananthapuramu, Andhra Pradesh, India

*Corresponding Author E-mail: poojithamallapu91@gmail.com

Online published on 4 July, 2020.

Abstract

In the present study the medicinal plant named Chloris paraguaiensis Steud was used to evaluate the gastro protective effect. The whole plant was shade dried and used for experimental study which was designed on four different models of induced gastric ulcers. This showed the dose dependent gastro protection that was compared to the omeprazole 20mg/kg/B.w (Standard Drug). Different parameters like GSH (μg/mg protein), ALP (IU/L), Gastric volume (ml/100g), pH (Unit) were estimated, which has shown significant results when compared to the standard drug.

Keywords

Chloris paraguaiensis Steud, omeprazole 20mg/kg/B.w, GSH, ALP, Gastric volume, Dose dependent