Design and Development of Ciprofloxacin Lipid Polymer Hybrid Nanoparticle by Response Surface Methodology

To develop lipid polymer hybrid nanoparticles by optimization techniques that is pioneering drug delivery systems of ciprofloxacin for using topical infection.

The formulation mainly prepared by a biodegradable eco-friendly and bioacceptable polymer of chitosan, lipid soya lecithin and can incorporate in the gel using carbopol solvent evaporation method. The experimental factorial design is 3D level of quadratic model is used to optimize the formulation at different ratio.

The determination of percentage drug entrapment efficiency, particle-size diameter and % loading capacity was studied. The optimized LPHNPs have particle size of 204.47 nm, loading efficiency of 74.49% and zeta potential of -4.56 mV was found. Ciprofloxacin released about 80% for 24 hours in vitro.

In current research, it can be concluded that the relative bioavailability of the drug in LPHNPs was significantly increased and used for the treatment of topical skin infection.