1Research Scholar, Department of Pharmacology, K.S Hegde Medical Academy, Mangaluru-575008, Karnataka, India
2Associate Professor, Department of Pharmacology, K.S Hegde Medical Academy, Mangaluru-575008, Karnataka, India
3Professor and HOD, Department of Pharmacology, K.S Hegde Medical Academy, Mangaluru-575008, Karnataka, India
4Additional Professor, Department of Physiology, K.S Hegde Medical Academy, Mangaluru-575008, Karnataka, India
5Professor, Department of Pathology, K.S Hegde Medical Academy, Mangaluru-575008, Karnataka, India
The present study aimed to evaluate dose required for oral D-galactose in aging induction on Wistar albino male rats, by evaluating Cognitive, Biochemical and Histological variables. Methods Male Wistar albino rats were randomly separated into six groups (n=6). Group 1 (Control) received distilled water; Group 2 (Standard) received 120mg/kg subcutaneous (S.C) D -galactose; Group 3,4,5 and 6 received oral D-galactose in dose of 100, 120, 150 and 200mg/kg body weight respectively.
Group 2 (120mg/kg) S.C and Group 3 (100mg/kg) orally administered D-galactose, showed increase in plasma MDA (Malondialdehyde) levels, appearance of lipofuscin pigment deposition in hepatocytes as well as increase in duration to find food along with total errors in Cognitive tests respectively compared to control. There is also significant decrease in plasma Glutathione levels in Group 3 compared to standard.
Oral D-galactose at dose of 100mg/kg can be employed as model for aging induction.
D-galactose, Radial maze, Heb William maze, Malondialdehyde (MDA), Glutathione (GSH), Lipofuscin
