1Dept. of Pharmacology, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-410044
2Indrayani Institute of Pharmaceutical Education and Research, Talegaon Dabhade, Pune-410507
3Aditya College of Pharmacy, Sherganj, Satna, Madhya Pradesh-485001
*Corresponding Author E-mail: dssdypcop@gmail.com
Online published on 10 August, 2020.
The effect of 70% ethanol extract of aerial part of Blumea lacera (BLEE) was investigated in rats to evaluate antiulcer activity against ethanol, indomethacin and pyloric ligation induced ulcer models. Pretreatment with BLEE (200mg/kg and 400mg/kg) has shown dose dependant decrease in ulcer index in all the experimental models of ulcers and also reduced the total acidity, free acidity, gastric volume and increased the pH (pyloric ligation model) with respect to control. Hence, it is concluded that BLEE possess significant antiulcer activity.
Blumea lacera, Antiulcer activity, ethanol, indomethacin, pyloric ligation
