Adjuvants employed in the fabrication of sublingual vaccines

Throughout the world needle-free type of vaccination has become priority as it eradicates the chance of unsafe and wrong use of needles and it reduces complexity of the procedure. Many routes have been explored in the same. Mucosal route is most important among others. Mucosal routes include nasal, oral, sublingual, buccal, ocular, rectal, vaginal routes. For treating allergic hypersensitivities, sublingual mucosa has been targeted for many years. Nevertheless, sublingual vaccine delivery received little attention recently. Latest studies demonstrated the capability of sublingual vaccination to induce mucosal and systemic responses against many antigens. (Like soluble proteins, live attenuated viruses and inter particulate antigens) This review summarizes the latest discoveries that proves the sublingual vaccine delivery is potential to provide protection against several mucosal pathogens.