1Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), Chennai, India
2Research Scholar, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), Chennai, India
3Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), Chennai, India
*Corresponding Author E-mail: hodpchemistry@velsuniv.ac.in
Online published on 16 September, 2020.
The genetic which alters the PRSS-1 (protease serine-1) gene results in chronic pancreatitis, which further causes pancreatic cancer. The equilibrium of the protease and anti-protease is altered by the RI22H (A sub-mutation of PRSS-1) which promote the onset of pancreatic cancer. Gene conversion is the major phenomenon which create the nucleotide changes that affect the axon part of thePRSS-1 gene. Genetic factors, Alcoholism, smoking, lack of the anti-oxidants were some of the factors, which causes the PRSS-1 gene mutations.
Mutation, Gene conversion, PRSS -1 gene, Pancreatic cancer
