Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2020
  • Volume: 13
  • Issue: 9

Neuroprotective potency of Tamarindus indica seed extract for preventing memory impairment in rat model of alzheimer's disease

  • Author:
  • Ihwan Narwanto Muhammad1,2,, Masruroh Rahayu3, Setyawati Soeharto4, Nurdiana4, Mochammad Aris Widodo4
  • Total Page Count: 6
  • Page Number: 4041 to 4046

1Doctoral Program of Medical Science, Faculty of Medicine, University of Brawijaya, Malang, Indonesia

2Department of Anatomy, Faculty of Medicine, University of Jember, Jember, Indonesia

3Department of Neurology, Faculty of Medicine, University of Brawijaya, Malang, Indonesia

4Department of Pharmacology, Faculty of Medicine, University of Brawijaya, Malang, Indonesia

*Corresponding Author E-mail: muhammadnarwanto@unej.ac.id

Online published on 16 September, 2020.

Abstract

To investigate the neuroprotective potency of Tamarindus indica seed extract (TSE) for Alzheimer's prevention-based on the pathogenesis of the disease.

Rats were divided into 6 groups normal, control, aluminum chloride (AlCl3), low, moderate and high dose of TSE. The Morris water maze test was used to evaluate the memory. Proinflammatory cytokines levels were estimated by enzyme-linked immunosorbent assay method. Malondialdehyde levels were measured by the thiobarbituric acid reactive substances method.

Administration of 50 mg/kg TSE were decreased cerebral cortex levels of proinflammatory cytokines and lipid oxidation products, and protected memory impairment due to the induction of AlCl3.

Data from this study confirmed the neuroprotective benefits of TSE for Alzheimer's prevention based on the pathogenesis of the disease. Further, these results could lead to the development of Alzheimer's prevention.

Keywords

Morris water maze, Aluminum chloride, IL1β, TNFα, Malondialdehyde