1Doctoral Program of Medical Science, Faculty of Medicine, University of Brawijaya, Malang, Indonesia
2Department of Anatomy, Faculty of Medicine, University of Jember, Jember, Indonesia
3Department of Neurology, Faculty of Medicine, University of Brawijaya, Malang, Indonesia
4Department of Pharmacology, Faculty of Medicine, University of Brawijaya, Malang, Indonesia
*Corresponding Author E-mail: muhammadnarwanto@unej.ac.id
Online published on 16 September, 2020.
To investigate the neuroprotective potency of Tamarindus indica seed extract (TSE) for Alzheimer's prevention-based on the pathogenesis of the disease.
Rats were divided into 6 groups normal, control, aluminum chloride (AlCl3), low, moderate and high dose of TSE. The Morris water maze test was used to evaluate the memory. Proinflammatory cytokines levels were estimated by enzyme-linked immunosorbent assay method. Malondialdehyde levels were measured by the thiobarbituric acid reactive substances method.
Administration of 50 mg/kg TSE were decreased cerebral cortex levels of proinflammatory cytokines and lipid oxidation products, and protected memory impairment due to the induction of AlCl3.
Data from this study confirmed the neuroprotective benefits of TSE for Alzheimer's prevention based on the pathogenesis of the disease. Further, these results could lead to the development of Alzheimer's prevention.
Morris water maze, Aluminum chloride, IL1β, TNFα, Malondialdehyde
