Olive and basil leave extracts protect against ibuprofen induced nephrotoxicity in albino rats

Ibuprofen is widely used as an analgesic and an anti-inflammatory agent with inappropriate usage. It exhibits adverse effects on the gastrointestinal tract (GIT), the kidney and the coagulation system. This study aims to evaluate the preventive effect of olive leave or basil leave extracts on the development of ibuprofen-induced nephrotoxicity. and renal oxidation renal lipid peroxidation and the proinflammatory cytokines interleukin (IL)-1β in ibuprofen administered group. While decreased serum levels of erythropoietin, total protein albumin renal production of catalase, glutathione and superoxide dismutase and anti-inflammatory cytokine interleukin(IL)-10 were recorded in the same group. Olive leave extract or basil leave extract ameliorate serum kidney biomarkers, renal oxidationand inhibit inflammatory reactions. Taken together, our findings indicate that olive leave extract or basil leave extract might be a valuable candidate for the prevention of nephrotoxicity in subjects receiving ibuprofen.