Relation between Serum cyclo oxygenase-2 values and Tumor characteristics in breast cancer patients

Background: Breast cancer hasa high incidence and death rates, and cyclooxygenase-2 (COX-2) is a promising enzyme in as prognostic and monitoring factor. Objective: Determination the relation between serum COX-2 concentrationand the stage and grade of breast cancer as a prognostic parameters. Methodology: This study is prospective, cross sectional type, include 30 women with breast cancer, met the study criteria. the serum COX-2 value was calibrated. The data was entered into the computer's SPSS program. Results: Patients were 48.33 ± 7.84 years old, and 70% of tumors in the first and second stages, while more than half of the tumors were in the third grade. The mean of serum COX-2 values was 372.31 ± 173.42 U/L.Serum COX-2 level was positively and significantly correlated with tumor stage and grade(P <0.01). Conclusion: Serum COX-2 values correlate with the stage and grade in breast cancers.