Research Journal of Pharmacy and Technology

Gastro retentive drug delivery system (GRDDS) is one of the novel approaches in the area of oral sustained release dosage forms. Drugs that are easily absorbed from gastrointestinal tract (GIT) and have short half-lives are eliminated quickly from the systemic circulation require frequent dosing to achieve suitable therapeutic activity. The floating drug delivery systems increase the Gastric retention time providing wide therapeutic efficacy. Mucoadhesive drug delivery systems interact with the mucus layer covering the mucosal epithelial surface, and mucin molecules and increase the residence time of the dosage form at the site of absorption. The drugs which have local action or those which have maximum absorption in gastric pH require increased duration of stay in GIT. Thus, floating and mucoadhesive drug delivery systems are advantageous in increasing the bioavailability and enhanced therapeutic activity. In this regard, this review aims to provide information of different floating and mucoadhesive approaches and their importance.