RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY

SCOPUS
  • Year: 2021
  • Volume: 14
  • Issue: 1

Analytical method development and validation of teneligliptin by UV spectroscopy

  • Author:
  • R Maruthi1, R.S. Chandan*, M Barath1, G Naveen Datta2, Merryl D'silva2, Kajal M Kumari3, Farhan Ahmad3, R Geetha3
  • Total Page Count: 4
  • Page Number: 75 to 78

1Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Sri Shivarathreeshwara Nagara, Mysuru-Karnataka, India, 570015

2Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Sri Shivarathreeshwara Nagara, Mysuru-Karnataka, India, 570015

3Department of Pharmacy Practise, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Sri Shivarathreeshwara Nagara, Mysuru-Karnataka, India, 570015

*Corresponding Author E-mail: rschandan@jssuni.edu.in

Online published on 22 April, 2021.

Abstract

The measurement of teneligliptin in a drug pure in compliance with the ICH Guidelines, an easy and extraction free UV spectrophotometric method, was developed and validated. At 246nm and linearity of concentration of 10–50μg/ml, the drug shows strong absorption. The process for relaying the drug reaction to MeOH was calculated by its absorption maximum (λmax) 246nm in order to achieve a colorless solution. In the 10–50μg/ml concentration range, the rule on beer complied. The calibration chart was found to be linear, and the coefficient of correlation (r2) was found to be 0.9952%. The experimental value LOD and LOQ parameters for the proposed procedure are measured, respectively, like 2.25 and 6.83μg/mL. Teneligliptin recovery was reported as 101.58%. To maximize the reaction condition, all of the parameters were analyzed.

Keywords

Teneligliptin, MeOH, Validation, ICH guidelines