1School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
2Bhaskar Herbaceuticals Pvt Ltd, Near Thakur Ram Campus, Aadarshnagar, Birgunj (Nepal).
Urolithiasis is one of the most important global challenge affecting individuals of different races, community, developed as well as developing countries. Presently available treatment provides insufficient relief from urolithiasis due to its reoccurrence. Ayurvedic drugs were successively used since ancient time for the treatment of urolithiasis. Hence therapeutically active drugs formulated in the form of tablet as well as syrup (Stonil syrup and tablet) and investigated against ethylene glycol induced urolithiasis in rats. All groups of rats received calculi inducing treatment for 28 days, comprised of 0.75% v/v ethylene glycol with 1% w/v ammonium chloride in distilled water ad libitum for 3 days to accelerate lithiasis followed by only 0.75% v/v ethylene glycol for 25 days The ingredients present in Stonil syrup and tablet are well known diuretic, analgesic, antimicrobial, antifungal, muscle relaxant and have anti-inflammatory drugs. In our present study, regular treatment with drugs causes prophylactic relief from urolithiasis while the group of rats received EG and ammonium chloride showed high degree of urinary alterations. Renal calcium oxalate deposition by EG (ethylene glycol) and ammonium chloride in rats is frequently used to mimic the urinary stone formation in humans.
Antiurolithiatic activity, Ethylene glycol, Urolithiasis
