1Environmentally Benign Laboratory, Dept. of Chemistry, University of Allahabad, Allahabad, Uttar Pradesh, India.
2United Institute of Pharmacy, Naini, Allahabad, Uttar Pradesh, India.
*Corresponding Author E-mail: shradha.06@gmail.com
Online published on 22 April, 2021.
Pyrimidine and its thione derivatives have found a wide range of application in medicine due to their pronounced biological activity. An attempt has been made to combine the toxophoric qualities of biologically versatile 2-amino-4-aryl thiazole and 5-arylidene-3-aryl rhodanine moieties and synthesizing pyrimidin-2-thione derivatives, VII(a-j). The compounds were screened for their in vitro antifungal potential against Aspergillus niger and Fusarium oxysporium. The results were promising as the compounds VII b, VII c, VII g and VII h displayed fungicidal action equivalent to that of commercial fungicide Dithane M-45 at 1000 ppm concentration.
Pyrimidine, Thione, Rhodanine, Fungicides, 2-amino-4-aryl thiazole, Agar-plate
