Formulation and evaluation of solid lipid nanoparticle of felbamate for improved drug delivery

Solid lipid nanoparticles are typically spherical in shape with average size of 1-1000nm in diameter. These are the alternatives to traditional colloidal carrier systems such as emulsions, liposomes, microspheres etc. Felbamate is a PEGylated phenylcarbamate derivative that acts as an antagonist of NMDA receptors. It is used as an anticonvulsant, primarily for the treatment of seizures in severe refractory epilepsy. It is slightly soluble in water with t1/2 of 4–6 hours. Solid lipid nanoparticles of felbamate are prepared by using lipids (glyceryl monostearate and glyceryl monooleate) with tween 80 as stabilizer. The prepared nanoparticle formulations were evaluated for their entrapment efficiency, assay, in-vitro drug release, particle size analysis, and stability. A formulation containing glyceryl monooleate, stabilized with tween 80 as surfactant showed prolonged drug release, smaller particle size, and narrow particle size distribution, as compared to other formulations.