1Dept. of Pharmaceutical Quality Assurance, BLDEA's SSM College of Pharmacy and Research Center, Vijayapur-586103
2Dept. of Pharmaceutical Chemistry, BLDEA's SSM College of Pharmacy and Research Center, Vijayapur-586103
3Dept. of Pharmaceutics, BLDEA's SSM College of Pharmacy and Research Center, Vijayapur586103
*Corresponding Author E-mail: santosh.karajgi@gmail.com
Online Published on 22 February, 2022.
An easy, fast, precise and cost effective First derivative UV estimation method has been investigated for the estimation of Capecitabine in various pharmaceutical dosage forms. The novel method was developed using Shimadzu Spectronic 1800 model UV-Visible Spectrophotometer. The region on the UV-spectrum between 240nm to 400nm in distilled water as the solvent was found to be suitable for the first derivative peak measurement of Capecitabine with a Linearity range throughout the concentrations of 40 microgram/ml to 80 microgram/ml. The method was successfully employed for the routine estimation on tablet dosage forms. The method was validated according to ICH guidelines. No interference from additives was observed.
Capecitabine, Estimation, Analytical method, First derivative, UV method
