1Research Scholar, School of Pharmaceutical Sciences, Jagatpura, Jaipur National University, Jaipur302017, India
2Department of Pharmacology, H.R. Institute of Pharmacy, Morta, Ghaziabad201003, Uttar Pradesh, India
3School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur302017, Rajasthan, India
4Department of Pharmacy, H.R. Institute of Pharmacy, Morta, Ghaziabad201003, Uttar Pradesh, India
*Corresponding Author E-mail: pooja_kamra125@rediffmail.com
Online Published on 22 February, 2022.
The present study aimed to evaluate the hepatoprotective potential of methanolic whole plant extract of Persicaria hydropiper in carbon tetrachloride (CCU) induced hepatotoxicity model. Hepatotoxicity was induced in rats by intraperitoneal administration of carbon tetrachloride (CCU) for seven days. The extract was thereafter administered at two different doses of 200 mg/kg and 400 mg/kg body weight for next seven days. Silymarin was used as a reference standard. The extract revealed hepatoprotective activity in dose dependent manner. The dose of 400 mg/kg exhibited maximum hepatoprotective ability as apparent from several evaluation parameters including liver function profile, bilirubin, antioxidant enzymes as well as histopathological investigation which was comparable to the standard drug Silymarin respectively. These findings sustenance the use of the extract as an adjuvant with existing therapy for treatment of liver ailments.
Hepatoprotective, Silymarin, Persicaria hydropiper, Hepatotoxicity, Antioxidants
