Research Journal of Pharmacy and Technology

SCOPUS
  • Year: 2021
  • Volume: 14
  • Issue: 11

Preparation,characterization and study of biological activity for some new derivatives mannich’s bases derived from shiffs bases

  • Author:
  • Nadia Sadiq Majeed1, Nada Ali Saleh2, Radhiyah Abd Baqi Al-Aldujaili3
  • Total Page Count: 8
  • Page Number: 6025 to 6032

1Chemistry Department Faculty of Education for girl, University of Kufa, Najaf

2Pharmaceutical Department Faculty of pharmacy, University of Kufa, Najaf

3Chemistry Department Faculty of Education for girl, University of Kufa, Najaf

*Corresponding Author E-mail: nadia.albobaid@uokufa.edu.iq

Online Published on 22 February, 2022.

Abstract

This paper involves synthesis new Mannich bases derived from Shiff’ bases which prepared from isatin by the reaction of isatin with different aromatic amines to prepare Shiff bases derivatives (M, G, B, R, X, S), then Shiff's bases derivatives reacted with formaldehyde and piperazine to produce Mannich bases derivatives (M1, G1, B1, R1, X1, S1). The third step included the assay of biological activity of all compounds against four types of pathogens bacteria (Staphylococcus aureus, Granutice tella adiacens) gram positive and (E. coli, Proteus mirabilis) gram negative the results exhibited excellent biological activity for all derivatives compared to antibiotics (Ampicillin and Ciprofloxacin) these structures were identified by FT-IR,1HNMRand 13CNMR.

Keywords

Isatine, Shiffs bases, Mannich's bases