1Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Madhav Nagar-576104, Manipal, Udupi, Karnataka, India
2Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Madhav Nagar-576104, Manipal, Udupi, Karnataka, India
*Corresponding Author E-mail: ruchi.verma@manipal.edu, ruchiverma_farma@yahoo.com
Online Published on 02 March, 2022.
Tuberculosis is one of the leading cause of increase in mortality rate in today's health care scenario. Due to increase frequency of drug resistant TB it is prudent to find new targets and promising targets for anti-tubercular activity. MmpL3 (Mycobacterial Membrane Protein Large 3) is one of the most effective and promiscuous targets for development of new drug for anti-tubercular therapy due to its cross resistance inhibition property. In this study we have presented atom based 3D QSAR and finger print based 2D QSAR models to study different structural and functional groups of Adamantyl urea derivatives and their action in MmpL3 inhibitory activity which will provide us the insight for designing better and far more effective anti TB drugs.
MmpL3 inhibitors, Atom based 3D QSAR, Fingerprint based 2D QSAR
