Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2021
  • Volume: 14
  • Issue: 12

Acid catalyzed synthesis of substituted-n-((1, 3-diphenyl-1h-pyrazol-4-yl) methyl) benzenamine

  • Author:
  • Havale Shrikant Hanumantappa12, Bhavani Singh1, Jaya Dwivedi1, Dharma Kishore1, S. Venkat Rao2
  • Total Page Count: 5
  • Page Number: 6442 to 6446

1Department of Chemistry, Banasthali University, Banasthali, Rajasthan, India-304022

2Department of Chemistry, SMS Research Center (ADSIR Approved Facility) SMS Pharmaceuticals Ltd; Hyderabad, Telangana, India500043

*Corresponding Author E-mail: shrikanthavale@yahoo.com, svr.org@gmail.com

Online Published on 02 March, 2022.

Abstract

A new derivative synthesis of Substituted-N-((1, 3-diphenyl-1h-pyrazol-4-yl) methyl) benzenamine has attempted by using commonly available key starting materials Acetophenone (1) and substituted phenyl hydrazine in presence of sulfuric acid catalyst and alcohol solvent to afford potential antiviral active analogues. The synthesis proceeds through Vilsmeier-Haack reaction followed by reductive amination by using sodium borohydride.

Keywords

(1, 3-diphenyl-1H-pyrazol-4-yl) methyl) benzenamine, Vilsmeier-Haack reaction, Reductive amination with sodium borohydride