Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2021
  • Volume: 14
  • Issue: 12

Long term toxicity study of a Siddha formulation Vetpalai thailam (VT) in Rats

  • Author:
  • Ganesh Shenoy1, Smita Shenoy2, Sathish B. Pai3, Nitesh Kumar4, Arul Amuthan5, Manjunath Shetty6, Mohandas Rao7, Bharath K. Rao8
  • Total Page Count: 6
  • Page Number: 6653 to 6658

1Selection Grade Lecturer, Department of Pharmacology, Melaka Manipal Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India-576104

2Professor and Head, Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India-576104

3Professor, Department of Dermatology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India-576104

4Assistant Professor, Department of Pharmacology and Toxicology, NIPER, Hajipur

5Assistant Professor, Department of Pharmacology, Melaka Manipal Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India-576104

6Senior Grade Lecturer, Department of Pharmacology, Melaka Manipal Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India-576104

7Professor, Department of Anatomy, Melaka Manipal Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India-576104

8Associate Professor, Department of Oral Biology, Melaka Manipal Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India-576104

*Corresponding Author E-mail: smita.shenoy@manipal.edu

Online Published on 02 March, 2022.

Abstract

Vetpalai thailam, a Siddha formulation is used topically as well as orally in the treatment of Psoriasis. Vetpalai thailam is prepared from the leaves of Wrightia tinctoria by insolation with coconut oil as the base. The adverse effect profile of VT has not been addressed and hence this study was taken up to assess the long term toxicity of VT in rats. A 90-day repeated dose toxicity study was performed by modifying the protocol described by OECD guideline 408 for testing chemicals. The study constituted of six groups consisting of six rats in each group. There was no mortality among the six study groups. No signs of toxicity and behavioural changes were observed. The histopathological examination of vital organs did not show any change in the architecture. Our study demonstrates that Vetpalai thailam does not cause any toxicity on long term use in rats.

Keywords

Vetpalai thailam, Wrightia tinctoria, Long term toxicity