RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY

PGV-6, HGV-6 and GVT-6 are three among curcumin analogs that successfully synthesized. These analogs have a monoketone on their structure. They have two kind of substituents on their aromatic rings, chloro-and hydroxyl-group. According to SAR analysis, these compounds will have a very good activity as antimicrobial agents. This research is aimed to study the antimicrobial activity of those three compounds by using micro-dilution method. Synthesis of PGV-6, HGV-6 and GVT-6 are carried out by using the aldol condensation reaction between a keton (cycopentanone, cyclohexanone, acetone) and aromatic aldehyde (3, 5-Dichloro-4-hydroxybenzaldehyde) in acid condition. First work was to see the inhibition percentage and the second experiment is to see the lowest sensitivity against microbes (bacteria and fungi), of three compounds by using micro-dilution method. From the results, it was obtained that the antimicrobial test against seven bacteria and one fungus, showed that PGV-6 only inhibits the growth of Staphylococcus aureus (SA) bacteria; HGV-6 inhibits Klebsiella pneumonia (KP), Escherichia coli (EC), Pseudomonas aeruginosa (PA) and Staphylococcus aureus (SA) bacteria; GVT-6 inhibits the growth of Klebsiella pneumonia (KP), Escherichia coli (EC), Staphylococcus aureus (SA), Streptococcus faecalis (SF) bacteria. None is active against Candida albicans (CA) fungi. GVT-6 is still sensitive against bacteria at 250 μL/mg of the concentration. GVT-6 is promising to be more developed as antimicrobial agents as confirmed by its docking study.