RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY

SCOPUS
  • Year: 2021
  • Volume: 14
  • Issue: 2

New quantitative technique for estimation of solubility of theophylline using hydrotropic solubilizing agents

1Department of Applied Science and Technology, A.C. Tech, Anna University, Chennai-600025, India.

2Petroleum and Chemical Engineering Programme Area, Faculty of Engineering, Universiti Teknologi Brunei, BE1410, Darussalam, Brunei.

3Department of Chemical Engineering, Pondicherry Engineering College, Puducherry-605014, India.

*Corresponding Author E-mail: c_jayakumar73@yahoo.com

Online published on 30 April, 2021.

Abstract

In the present study, hydrotropic solubilization technique has been used to solubilize the poorly water soluble anti-diuretic drugs such as theophylline for its spectrophotometric analysis. Sodium salicylate and resorcinol solutions of strength 7.5 M and 5.5 M respectively, have been used as a hydrotropic agent. Compared to the solubility in distilled water, a twofold increase in the aqueous solubility of theophylline with respect to sodium salicylate (7.5 M) and 1.3 times enhancement in the solubility of theophylline with regard to resorcinol (5.5 M) have been observed. The interference of the hydrotropic agent in the analysis was found to be nil. Also, the hydrotrope is economical and free from pollution. The proposed method is new, simple, correct and reproducible. Statistical data proved the accuracy, reproducibility, and precision of the proposed method.

Keywords

Hydrotropes, Theophylline, Solubility, Spectrophotometry, Regression Coefficient