RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY

Objective: The Aim of the study was to find out the nephroprotective activity of dichloromethane extract of Alstonia scholaris in Gentamycin induced nephrotoxicity in rats. Methods: Dichloromethane extract of leaves of Alstonia scholaris was studied for its Nephro-protective activity in animal experimental models. Nephrotoxicity was induced by Gentamycin. Nephro-protective activity of dichloromethane extract of Alstonia scholaris at doses 200mg/kg p.o. and 400mg/kg p.o. in models of nephro-protective activity in. Gentamycin induced nephrotoxicity. The study period was 14 days for Gentamycin induced nephrotoxicity models. Results: In Gentamycin treated groups of animals the concentration of serum, urea, Creatinine, Uric acid, Total protein and Urine Urea, uric acid, creatinine were considerably increased than the normal animals which indicates severe nephrotoxicity. Conclusion: On evaluating biochemical parameters it was found that the dichloromethane extract of leaves of Alstonia scholaris showed nephro-protective activity in both Gentamycin induced nephrotoxicity the models due to presence of terpenoids, alkaloids or flavonoids.