Design and preparation lipid polymer hybrid nanocarrier as pulmonary dispersion system using a Novel microwave method

Since the birth of humanity to this day, there are many epidemics and deadly diseases that people are exposed to it. Many studies show the use of myrtle and peppermint essential oils (EOs) which has proven to be very effective against many viral, bacterial and fungal diseases. Currently, there is a fierce attack from a deadly virus that causes severe acute respiratory syndrome coronavirus (SARS-CoV-2) disease. The lipid-polymer hybrid nanocarriers dispersion system (F1-F6) was prepared by a new microwave method. The thermodynamic outcomes indicate that all the formulations show an excellent physical stability. The average colloidal carrier size was within nano size diameter. The polydispersity index (PDI) was from (0.011 to 0.03). The absolute values of zeta potential was (31.1mV to 33.4mV). The viscosity data of nanocarrier systems indicate non-Newtonian pseudoplastic rheological properties of prepared F1-F6. The selected colloidal dispersion was F6 due to contain a greater loading quantity of myrtle and peppermint EOs. This research aims to prepare a lipid-polymer hybrid nanocarrier system to be given by nebulization through the pulmonary route to achieve the rapid therapeutic efficacy of myrtle and peppermint EOs using a novel microwave method.