Orexin a hormone and its relation to coronary heart diseases

The research included determination of the level of orexin-A hormone in coronary heart patients and compared to the control group. The results showed that the normal mean level of Orexin A hormone in serum was (344. 47± 6.51pg/mol) in control group for both sexes with ages range between (20-more of 50) year and there was a significant decrease in level of Orexin A in coronary heart patients compared to control group. Also, it has been found that Orexin A level was not affected by age and sex, while there was a significant decrease in hormone level according to body mass index (BMI), also a significant decrease in hormone level in smoking patients compared to non-smoking has been found. The results showed a significantly increase of activity enzymes Peroxidase, Lactate dehydrogenase, Creatine Kinase and concentration of Cyststin-C, Copper, total cholesterol, triglyceride, low density lipoprotein-cholesterol and very low density lipoprotein-cholesterol also the results showed a significantly decreasing of Arylestase activity and concentration of high density lipoprotein-cholesterol in patients compared to control group. Correlation coefficients of Orexin A hormone with some clinical parameters were examined in control and patients. The results showed that Orexin A has a significant negative correlation with concentration of total cholesterol, triglyceride, LDL-C, VLDL-C, cystatin-c, copper and peroxidase activity in control and patients group, and with Iron in control group. Also, there was a significant positive correlation with concentration of HDL-C and Arylesterase activity in control and patients group. It was concluded that low level of Orexin A hormone is a risk of coronary heart disease and Orxine A has a critical role in coronary heart disease. Moreover, the level of the hormone could be used as a marker for coronary heart disease and its role of obesity.