Synthesis and evaluation of antimicrobial, antitubercular and anticancer activities of dihydrobenzimidazole thiopyranooxazinone derivatives

The present study shown that the dihydrobenzimidazole thiopyranooxazinone derivatives were efficiently synthesized, which was further structurally elucidated by analytical as well as spectral studies. All these compounds screened for in vitro antimicrobial, antitubercular and anticancer activities. The result of antimicrobial activity revealed that the compounds having average to potent activity against Bacillus subtilis, Escherichia coli (antibacterial) and Aspergillus niger (antifungal) as compared to ciprofloxacin and fluconazole respectively. Compounds DPK3d1 exhibited potent antitubercular activities against Mycobacterium tuberculosis as compared to pyrazinamide, ciprofloxacin and streptomycin. Also, in cytotoxic studies compounds DPK3d3, DPK3d4 and DPK3d5 revealed that the potent activity against selected human cell line A459 as compared to Adriamycin.