Formulation and evaluation of theophylline Lozenges

Theophylline hard candies lozenges were prepared to provide slow release of medicament for the treatment of wheezing, shortness of breath, and breathing problems caused by asthma. It makes breathing easier by relaxing and opening air passage in the lungs. There are several dose forms like syrups, tablets, ODT`s offered within the market however still there's would like for brand new dose forms that acts effectively and domestically for paediatric and people with difficulty in swallowing. The local acting mechanism of theophylline makes it more suitable to formulate as lozenges. The hard candy lozenges were formulated using sugar as a base Locust Bean gum, Kondagogu gum and Neem gum are used as natural polymers. The usage of corn syrup in the formulation made the lozenges smooth which helped in improving the elegance of the formulation. Stevia was used as sweetener. Sweeteners along with flavours are used to mask bitter taste of drug. The formulation of hard Candy lozenges was subjected to physico-chemical as well as in vitro drug release. Among all the formulations of hard candy lozenges F10 had shown in vitro drug release of 98.9% at the end of 30 minutes.