Design, optimization and evaluation of telmisartan chronotherapeutics press coated tablets employing as novel synthetic disintegrate and as novel coated Chronotherapeutic polymers

Starch Glutarate prepared by reacting potato starch with Glutaric acid at elevated temperatures was found to be a white, crystalline powder. Starch glutarate prepared exhibited excellent flow characteristics it was insoluble in water and aqueous fluids of acidic and alkaline buffers. It also exhibited good swelling (70%) in water. It has no gelling property when heated at 100Co in water for 30 min. It is considered as a promising disintegrant in tablet formulations and was evaluated as disintegrant in tablet formulations. Tablets of Telmisartan were prepared by direct compression method employing starch glutarate at 0–10% as novel super disintegrate and were evaluated. In the present research work, 2³ factorial design was used for optimization of level of independent variables (starch glutarate, sodium starch glycolate and croscarmellose sodium) on dependent variables (disintegration time, water absorption, wetting time and percent released in 5 minutes) in the formulations. The optimized formula was further press coated by synthetic controlled time released polymers such as starch acetate, starch succinate in varying ratios. The best formulation was selected based on post-compression parameters and dissolution data was subjected to accelerated stability studies for 3 month. Amongst 5 formulations prepared for coating tablets we are F2CC1 produced convincing results with a maximum cumulative drug release of 99.21%. in 8 hr. By virtue of its release pattern and delivering the drug at the right time, right place and in right amounts, the developed delivery system holds good promises of benefiting the patients suffering from hypertension.