Synthesis, characterization, Insilico and Invitro screening of newly synthesized schiff bases

A set of novel schiff bases (C1-C4) were synthesised by conventional method. The purity and progress of the reaction was done by thin layer chromatography and characterisation by IR spectroscopy. The derivatives have been screened for their antimicrobial activity by the disc plate diffusion technique using DMSO as solvent on different species of pathogenic bacteria that is E. coli and S. aureus. It has been found that all the derivatives were active against both the organisms, but more effective towards E. coli. The results obtained from molinspiration cheminformatics revealed that all the compounds obeyed Lipinski rule of five with high bioactive scores for compound C3 as enzyme inhibitor (0.44) and compound C4 for protease inhibition (0.26). The BOILED egg predicted that out of four compounds, C3 is outside of the range of the plot.