Removal of Toxic heavy metal ions by the formation of complex with Theophylline (Therapy drug): Thermodynamic and kinetic study

Chelation therapy drug is an established treatment for heavy metal toxicity. Chelation therapy agents that remove toxic metal ions such as Lead, Nickel, Zinc, iron and copper from the body by removing them from intracellular or extracellular spaces. The present study create all the experiment were performed at different temperature (303, 308, 313, 318, 323)°K. The UV-Vis measurements were carried out for the metal-drug complex by Spectrophotometric method. The absorption Spectrum of the mixture of drug and Nickel ion shows a batho chromic (red) shift in λmax, the absorbance change caused by complex arrangement between the Nickel ion and drug. The stoichiometry of the formed complex was investigated by the method of continuous variation and it was found (1: 1), In the present work we investigate the stability constant of therapy drug with Ni(II) ion using water at (298K, 303, 308K, 313, 318)°K, We employed to determine (Ni(II)-ligand) complex stability constant (logK) values. It is observed that Ni (II) ion forms 1: 1 complex. The thermodynamic parameter ΔGo, ΔHo and ΔSo were calculated from values of stability constant at different temperatures. The formations of (Ni(II)-drug) complex were found to be spontaneous and indothermic in nature. Chemical kinetics show, the Complication of drug with Ni ion was found to follow the second order reaction.