RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY

SCOPUS
  • Year: 2021
  • Volume: 14
  • Issue: 3

Some complexes of Zink (II) and Manganese (II) with schiff base derived from nicotinamide, synthesis and characterization, antibacterial evaluation

Department of Chemistry, College of Education of Pure Science, University of Mosul, Iraq

*Corresponding Author E-mail: ranaalbustani@uomosul.edu.iq

Online published on 30 April, 2021.

Abstract

Manganese (II) and Zinc (II) Complexes with O-aminobenzylidenenicotinamide were synthesized. And characterized by using physicochemical Technique and spectroscopic analysis such as melting point determination, conductivity measurements, Molar efraction (CHN elemental analysis) and infrared spectroscopy (1H NMR, 13C-NMR), The antibacterial activity of the prepared complexes was screened against several bacterial strains namely S. aureus, E. coli, Proteus mirabilis and P. aeruginosa. The antibacterial screening tests elicit that both complexes besides Schiff bases exhibited promising antibacterial activity against these microorganisms so that they are of improved antibacterial activity than the parent drugs. The above ligand formed ionic complexes having general formulae [M (OABNA)2]X2 in neutral medium having octahedral geometries, M= Mn, Zn, X= Cl, NO3, CH3COO, OABNA = ortho-aminobenzylidenenicotinamide, hexa coordinated mononuclear, complexes were investigated by this study.

Keywords

O-aminobenzylidenenicotinamide, Nicotinamide Mn and Zn complexes, Schiff base, Antibacterial