Formulation and Evaluation of sublingual tablet of tenofovir alafenamide using solid dispersion method

The target of this analysis is to arrange sublingual tablets of Tenofovir alafenamide with the aim to increase its solubility and therefore rising its oral bioavailability. Materials and Methods: Pure drug, polymer, and different excipients were Characterised by infrared spectrometry and differential scanning measurement. The solid dispersion of Tenofovir alafenamide was ready exploitation beta cyclodextrin and PEG. The solubility of Tenofovir alafenamide was exaggerated by formulating as solid dispersion by kneading techniques. The ready solid dispersion was additional used in the formulation of these tablets. Tablets were developed exploitation superdisintegrants such as crospovidone and sod starch glycolate. In a total range batches of formulations from F1 to F6 were ready by variable superdisintegrants concentration. All these formulations were with success ready and evaluated1. However, results of parameters evaluated conclude that among all ready formulations of these pill have and located to be exaggerated solubility and bioavailability.