1Doctoral Degree Study Program in Military Dentistry Science at Faculty of Dentistry, Padjadjaran University, Bandung, Indonesia
2Department of Oral Biology at Faculty of Dentistry, Padjadjaran University, Bandung, Indonesia
3Department of Radiology at Faculty of Dentistry, Padjadjaran University, Bandung, Indonesia
4Department of Pedodontist at Faculty of Dentistry, Padjadjaran University, Bandung, Indonesia
5Veterinary Teaching Hospital, Bogor Agricultural Institute, Bogor, Indonesia.
6Department of Research and Development, Indonesian Naval Dentistry Institute Ladokgi REM, Indonesian Navy Headquarters
*Corresponding Author E-mail: arifrachman8888@gmail.com
Online published on 3 June, 2021.
Mesenchymal stem cells (MSCs) are an important class of stem cells that can differentiate into osteoblasts, chondrocytes, and adipocytes. MSCs must express CD105, CD73, and CD90 and differentiate into osteoblasts, adipocytes, and chondroblasts. The beneficial effects of MSCs on bone remodeling are mainly provided by a paracrine effect. In bone regeneration, implanted hADMSCs secrete various osteoblast-activating factors, receptor activator of nuclear factor kappa-B ligand (RANKL), BMP-2, BMP-4, hepatocyte growth factor (HGF) and bone-related extracellular matrix proteins. The MSCs possess multipotent capabilities, paracrine, autocrine, and migration capacity to the tissue, directly initiating healing and regeneration with a specified standard. hADMSCs has demonstrated bone regenerative capabilities. DLX5 and RUNX2 as potential bone regeneration references by looking at the osteogenic cells of each source cell. The ability of hADMSC bone regeneration is higher than hUCBMSC due to the capacity of hADMSC osteogenesis which leads to bone and cartilage formation.
Bone Regeneration, Mesenchymal stem cell, Adipose, Umbilical Cord Blood, Osteogenesis
