1Department of Pharmacy, Brac University, 66 Mohakhali, Dhaka1212, Bangladesh
2Department of Pharmacy, Daffodil International University, 102 Mirpur Road, Dhaka1207, Bangladesh
3Department of Biochemistry and Molecular Biology, Trust University, Barishal, Ruiya, Nobogram Road, Barishal-8200, Bangladesh
4King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia
5Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
*Corresponding Author E-mail: tanvir_kbr@yahoo.com, tanvir.kabir@bracu.ac.bd
Online published on 3 June, 2021.
Crassocephalum crepidioides belongs to the Asteraceae family and the leaves of the plant were used in the phytochemical screening. The objective of this study was phytochemical analysis of C. crepidioides in order to evaluate its antioxidant, thrombolytic and cytotoxic effects. In this study, DPPH assay and total phenolic content (TPC) were used to evaluate the antioxidant property. Brine shrimp lethality test was performed to find the cytotoxicity. The TPC of methanolic extract of C. crepidioides was 637.22 mg/gm and gallic acid was standard in this procedure. The IC50 value of the plant extract of DPPH assay was 136.016 μg/mL obtained by using ascorbic acid as reference standard. Furthermore, the obtained IC50 value of ascorbic acid was 94.12 μg/mL. In this study, lethal concentrations of vincristine sulfate and the plant extract were 3.064 μg/mL and 69.245 μg/mL respectively. Indeed, the plant exhibited significant antioxidant, cytotoxic and thrombolytic activity.
Total phenolic content, Antioxidant, DPPH assay, Thrombolytic activity, Cytotoxicity
