1Department of Pharmaceutics and Pharmaceutical Technology, Padjadjaran University, Indonesia
2Pharmacy Study Program, STIKes Salsabila, Serang Banten, Indonesia
3Department of Pharmacology and Clinical Pharmacy, Padjadjaran University, Indonesia
*Corresponding Author E-mail: sofia240586@gmail.com
Online published on 25 August, 2021.
Apigenin is a flavonoid belonging to a flavone subclass that is reported to have many benefits and less toxic than other flavonoid groups.
The purpose of this study is to evaluate antinephrolithiasis activity of modified Hot Melt Extrusion (HME) apigenin formulas with Soluplus® and Kollidon® VA 64 polymers in rats.
In this study, rats were administered ethylene glycol 0.75% and ammonium chloride 2% as inducing agents for formation of kidney stone. Rats in each group were given the formulas of apigenin without HME, or apigenin with HME soluplus® polymer and apigenin with HME Kollidon® VA 64 polymer every day for seven days. The concentration of calcium oxalate in the kidney and the urine was measured using the atomic absorption spectrophotometer (AAS). Urine volume and urine pH were also measured.
The results of this study indicated that the apigenin formulas with HME soluplus® polymers can shed kidney stones at a dose of 4.8mg/kg of body weight. Its effect was stronger than the apigenin formula with Kollidon®.
The formula of Apigenin with HME Soluplus® polymers is better than that of Kollidon® polymers in removing kidney stones with the ratio of 10:90 at a dose of 4.8mg/kg.
Antineprolithiasis, Apigenin from HME, Calcium Oxalate, Soluplus®, Dan Kollidon®, Polymers
