1Department of Veterinary Basic Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, Indonesia
2Doctoral Program in Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, Indonesia
*Corresponding Author E-mail: rochmah-k@fkh.unair.ac.id
Online published on 25 August, 2021.
Capsicum annum L. is a potential natural plant that have a lot of various pharmacological effects, including as anticancer agent. This study Aim to analyze Capsicum annum extract (CAE) on T47D cells. CAE (10, 20, 40, 60, 80μg/mL) treated on T47D cells to determined IC50 value by MTT assay. Apoptosis induction is also investigated through caspase-3 expressions (IC50, 2IC50). The present study showed that CAE suppress T47D cells proliferation with IC50 value of 75.81μg/mL. The caspase-3 expression on 2IC50 is higher (67.16%) than IC50 (52.16%). This result indicate that CAE has ability as anticancer agent by inhibiting cell growth and induce apoptosis through caspase-3 expression on T47D cells. Further study of CAE holds potential for novel therapies of cancer prevention and treatment.
Capsicum annum, Cytotoxicity, Apoptosis
