Microspheres as therapeutically effective multiparticulate drug delivery system: A systemic review

Therapeutic research and development are increasingly focusing on delivery systems which enhance desirable objectives while minimizing side effects. Nowadays Dose dumping is a major problem of single particulate dosage forms. So there is a need of extended release Multi-particulate drug delivery systems. Microspheres are multiparticulate drug delivery systems which are prepared to obtain prolonged or controlled drug delivery to improve bioavailability, stability and to target the drug to specific site at a predetermined rate. In strict sense, they are spherical empty particles. The pharmaceutical scientists have achieved a great success in developing most therapeutic systems with suitable natural polymer. Multi-particulate drug delivery systems are developed to address the challenges of drug development. A well designed drug delivery system can overcome some of the problems of conventional therapy and enhance the therapeutic efficacy of given drug. It is the reliable means to deliver the drug to the target site specifically. They received much attention for prolonged release as well as targeting to treat various diseases. This Current review outlines the transient account of classification, methods of preparations, its application and also the evaluation characterization for their efficiency of microspheres.