1Assistant Professor, SHEAT College of Pharmacy, Varanasi, Uttar Pradesh - 221210, India
2Assistant Professor, Department of Pharmaceutical, Engineering, and Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi, Uttar Pradesh - 221005, India
3Director, Varanasi College of Pharmacy, Varanasi, Uttar Pradesh - 221105, India
4Professor, Department of Botany, MMV, Banaras Hindu University, Varanasi, Uttar Pradesh - 221005, India
5Assistant Professor, Department of Ceramic Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi, Uttar Pradesh -221005, India
*Corresponding Author E-mail: tanusrivns@gmail.com
Online published on 25 August, 2021.
Green synthesis of two coordination complexes of zinc acetate with NAN moiety on quercetin, which is a flavonoid is carried out. The complexes were obtained in high yields (> 97%) by grinding methods without the involvement of any solvent. Neither catalyst nor any additives were needed to perform the reactions. It was characterized by FT-IR, UV-Vis, NMR, HRMS, and elemental analysis. Antioxidant activity was done through the DPPH method which was compared with ascorbic acid and ligand (Quercetin). The study reveals that Complex 1 (IC50 163.093μg/ml) has significant free radical scavenging activity as compared to complex 2 (IC50 258.683μg/ml). Biological activity was performed against microbes (E. coli and S. aureus). MIC value of complex 1 (15.50μg/ml E. coli, 7.18μg/ml S. aureus) was found more significant as compared to complex 2 (22.51μg/ml E. coli, 18.62μg/ml S. aureus) and quercetin.
Solid-state, Coordination complexes, DPPH, Minimum inhibitory concentration
