1Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia
2Brain Research Laboratory Faculty of Pharmacy, Universiti Teknologi MARA (UiTM) Selangor, 42300Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia
3Pharmaceutical and Life Sciences CoRe, Universiti Teknologi MARA (UiTM), 40450Shah Alam, Selangor Darul Ehsan, Malaysia
*Corresponding Author E-mail: meor@uitm.edu.my
Online published on 25 August, 2021.
In this study, the solute-cosolute interaction, solute-solvent interaction involved in the solubilisation process of ARG solutions and LVS-ARG solution systems are illustrated. The sound velocity values of both solution systems were determined at varying concentrations of ARG (0.01–0.8 mol.dm−3) at 298.15 K. Next, the refractive index and the density of the solution systems was measured at temperature range from 298.15 to 313.15K. Acoustic and volumetric parameters such as isentropic compressibility (KS), apparent isentropic molar compressibility (Ks®), relative association (Ra), acoustic impedance (Z), internal pressure (n), free volume (V), molar volume (®v°), molar expansibility (®e°) were calculated from sound velocity and density data. From the study, an increasing trend in sound velocity was observed with the increase in ARG concentration while compressibility values showed opposite trend. Additionally, solute-solvent interaction and structural effects of water for ARG and LVS-ARG systems are discussed regarding the changes in acoustic parameters.
Acoustic Parameter, Arginine, Lovastatin, Refractive Index, Solute-Solvent Interactions, Sound Velocity
